教育背景：
2011/09-2016/06 吉林大学 计算机科学与技术学院 博士
2008/09-2011/06 吉林大学 计算机科学与技术学院 硕士
2004/11-2006/07 吉林大学 生命科学学院 生物技术第二学位
2004/09-2008/06 吉林大学 计算机科学与技术学院 本科
2014/07-2014/12 东芬兰大学 健康科学学院 交换生
2010/08-2011/02 东芬兰大学 健康科学学院 交换生
工作经历：
2016/07-2019/06 澳门大学 健康科学学院 博士后研究员
2019/06-2023/07 汕头大学 工学院 副教授
2023/07-至今 汕头大学 数学与计算机学院 副教授
教学课程：
《数据结构与算法》、《数据可视化》
发表的学术论文：
Chen, Liang; Sun, Huiyan; Wang, Changliang; Yang, Yang; Zhang, Menglei; Wong, Garry*; miRNA arm switching identifies novel tumour biomarkers, EBioMedicine, 2018, 38: 37-46. (SCI期刊论文)
Mei Zhuang; Waner Yan; Yifei Xiong; Zhilin Wu; Yuping Cao; Edmond Sanganyado; Bupe A. Siame; Liang Chen*; Yechezkel Kashi; Ka Yin Leung*; Horizontal plasmid transfer promotes antibiotic resistance in selected bacteria in Chinese frog farms, Environment International, 2024, 190: 108905. (SCI期刊论文)
Chen, Liang; Heikkinen, Liisa; Wang, Changliang; Yang, Yang; Sun, Huiyan; Wong, Garry*; Trends in the development of miRNA bioinformatics tools, Briefings in Bioinformatics, 2019, 25(5): 1836–1852. (期刊论文，2022至2025年ESI高被引论文)
Chen, Liang; Wang, Changliang; Sun, Huiyan; Wang, Juexin; Liang, Yanchun; Wang, Yan; Wong, Garry; The bioinformatics toolbox for circRNA discovery and analysis, Briefings in Bioinformatics, 2020. (SCI期刊论文，2022至2025年ESI高被引论文)
Zhuang, Mei; Achmon, Yigal; Cao, Yuping; Liang, Xiaomin; Chen, Liang; Wang, Hui; Siame, Bupe A.; Leung, Ka Yin*; Distribution of antibiotic resistance genes in the environment, Environmental pollution, 2021, 285(2021). (SCI期刊论文，2022至2025年ESI高被引论文)
Chen, Yuqi#; Liang, Xiaomin#; Du, Wei; Liang, Yanchun; Wong, Garry; Chen, Liang*; Drug–Target Interaction Prediction Based on an Interactive Inference Network, International Journal of Molecular Sciences, 2024, 25(14): 7753. (SCI期刊论文)
Chen Liang; Heikkinen Liisa; Knott K Emily; Liang Yanchun*; Wong Garry; Evolutionary conservation and function of the human embryonic stem cell specific miR-302/367 cluster, Comparative Biochemistry and Physiology D-Genomics & Proteomics, 2015, 16: 83-98. (SCI期刊论文)
Chen, Liang; Heikkinen, Liisa; Wang, ChangLiang; Yang, Yang; Knott, K. Emily; Wong, Garry; miRToolsGallery: a tag-based and rankable microRNA bioinformatics resources database portal, Database, 2018, 2018: bay004. (SCI期刊论文)
Huang, Xiaobing; Wang, Changliang; Zhang, Tianjiao; Li, Rongzhen; Chen, Liang; Leung, Ka Lai; Lakso, Merja; Zhou, Qinghua; Zhang, Hongjie; Wong, Garry*; PIWI-interacting RNA expression regulates pathogenesis in a Caenorhabditis elegans model of Lewy body disease, Nature Communications, 2023, 14(1): 6137. (SCI期刊论文)
Ma, Rong; Chen, Liang; Hu, Ningyun; Caplan, Steve*; Hu, Guoku*; Cilia and Extracellular Vesicles in Brain Development and Disease, Biological Psychiatry, 2024, 95(11): 1020-1029. (SCI期刊论文)
Zhang, Tianjiao; Chen, Liang; Zhu, Haibin; Wong, Garry; Mammalian piRNA target prediction using a hierarchical attention model, BMC bioinformatics, 2025, 26(1): 50. (SCI期刊论文)
Wang, Changliang; Chen, Liang; Zhang, Menglei; Yang, Yang; Wong, Garry*; PDmethDB: A curated Parkinson's disease associated methylation information database, Computational and Structural Biotechnology Journal, 2020, 18: 3745-3749. (SCI期刊论文)
Wang, Changliang; Chen, Liang; Yang, Yang; Zhang, Menglei; Wong, Garry; Identification of bladder cancer prognostic biomarkers using an ageing gene-related competitive endogenous RNA network, Oncotarget, 2017, 8(67): 111742. (SCI期刊论文)
Sun, Huiyan; Chen, Liang; Cao, Sha; Liang, Yanchun; Xu, Ying*; Warburg Effects in Cancer and Normal Proliferating Cells: Two Tales of the Same Name, Genomics Proteomics Bioinformatics, 2019, 17(3): 273-286. (SCI期刊论文)
Chivero, Ernest T.*; Dagur, Raghubendra Singh; Peeples, Eric S.; Sil, Susmita; Liao, Ke; Ma, Rong; Chen, Liang; Gurumurthy, Channabasavaiah B.; Buch, Shilpa; Hu, Guoku*; Biogenesis, physiological functions and potential applications of extracellular vesicles in substance use disorders, Cellular and Molecular Life Sciences. (SCI期刊论文)
Chen, Sentao; Chen, Liang; Joint-product representation learning for domain generalization in classification and regression, Neural Computing & Applications, 2023, 35(22): 16509-16526. (SCI期刊论文)
Lin, Kaihao; Lin, Wenxia; Guo, Zhikai; Chen, Cuihong; Chen, Liang; Cai, Xianbin; Plasma Exosomal miRNA Expression and Gut Microbiota Dysbiosis Are Associated with Cognitive Impairment in Alzheimer's Disease, Frontiers in Neuroscience, 2025, 19: 1545690. (SCI期刊论文)
Wang, Juexin; Chen, Liang; Wang, Yan; Zhang, Jingfen; Liang, Yanchun*; Xu, Dong; A Computational Systems Biology Study for Understanding Salt Tolerance Mechanism in Rice, PLos One, 2013, 8(6): e64929. (SCI期刊论文)
Jiang Yuexu; Wang Yan*; Pang Wei; Chen Liang; Sun Huiyan; Liang Yanchun; Blanzieri Enrico; Essential protein identification based on essential protein-protein interaction prediction by Integrated Edge Weights, Methods, 2015, 83: 51-62. (SCI期刊论文)
Wang, Chenyin; Saar, Valeria; Leung, Ka Lai; Chen, Liang; Wong, Garry; Human amyloid β peptide and tau co-expression impairs behavior and causes specific gene expression changes in Caenorhabditis elegans, Neurobiology of Disease, 2018, 109: 88-101. (SCI期刊论文)
Wang, ShiBin; Wang, YuanYuan; Zhang, Qing E; Wu, ShuoLin; Ng, Chee H; Ungvari, Gabor S; Chen, Liang; Wang, ChunXue; Jia, FuJun; Xiang, YuTao; Cognitive behavioral therapy for post-stroke depression: A meta-analysis, Journal of Affective Disorders, 2018, 235: 589-596. (SCI期刊论文)
Sun, Huiyan; Liang, Yanchun; Wang, Yan; Chen, Liang; Du, Wei; Jiang, Yuexu; Shi, Xiaohu; Link Prediction Based on Extended Local Path Gain in Protein-Protein Interaction Network, Tehnički vjesnik, 2019, 26(1): 177-182. (SCI期刊论文)
Wang, Changliang; Chen, Liang; Yang, Yang; Zhang, Menglei; Wong, Garry; Identification of potential blood biomarkers for Parkinson’s disease by gene expression and DNA methylation data integration analysis, Clinical Epigenetics, 2019, 11(1): 24. (SCI期刊论文)
Linjing Shen; Changliang Wang; Liang Chen; Ka Lai Leung; Esther Lo; Merja Lakso; Garry Wong; TDP-1/TDP-43 potentiates human α-Synuclein (HASN) neurodegeneration in Caenorhabditis elegans, Biochimica et Biophysica Acta-Molecular Basis of Disease, 2020, 1866(10): 165876. (SCI期刊论文)
Liu, Mengyuan; Wang, Ruoyu; Sun, Xuren; Liu, Yuting; Wang, Zhi; Yan, Jin; Kong, Xiangyu; Liang, Shanshan; Liu, Qiuge; Zhao, Tong; Ji, Xuening; Wang, Gang; Wang, Fuguang; Wang, Guan; Chen, Liang; Zhang, Qingfu; Lv, Weipeng; Li, Heming; Sun, Mingjun; Prognostic significance of PD-L1 expression on cell-surface vimentin-positive circulating tumor cells in gastric cancer patients, Molecular Oncology, 2020, 14(4): 865-881. (SCI期刊论文)
Shen, Linjing; Wang, Changliang; Chen, Liang; Wong, Garry*; Dysregulation of MicroRNAs and PIWI-Interacting RNAs in a Caenorhabditis elegans Parkinson's Disease Model Overexpressing Human alpha-Synuclein and Influence of tdp-1, Frontiers in Neuroscience, 2021, 15: 600462. (SCI期刊论文)
Du, Wei; Sun, Yu; Bao, Hui-Min; Chen, Liang; Li, Ying*; Liang, Yan-Chun*; DeepHBSP: A Deep Learning Framework for Predicting Human Blood-Secretory Proteins Using Transfer Learning, Journal of Computer Science and Technology, 2021, 36(2): 234-247. (SCI期刊论文)
Huang, Xiaobing; Wang, Changliang; Chen, Liang; Zhang, Tianjiao; Leung, Ka Lai; Wong, Garry*; Human amyloid beta and a-synuclein co-expression in neurons impair behavior and recapitulate features for Lewy body dementia in Caenorhabditis elegans, Biochimica et Biophysica Acta-Molecular Basis of Disease, 2021, 1867(10): 166203. (SCI期刊论文)
Sergio Carracedo; Lisa Lirussi; Lene Alsøe; Filip Segers; Changliang Wang; Zdenka Bartosova; Pavol Bohov; Nuriye B. Tekin; Xiang Yi Kong; Q. Ying Esbensen; Liang Chen; Anna Wennerström; Penelope Kroustallaki; Deborah Ceolotto; Anke Tönjes; Rolf Kristian Berge; Per Bruheim; Garry Wong; Yvonne Böttcher; Bente Halvorsen; Hilde Nilsen; SMUG1 regulates fat homeostasis leading to a fatty liver phenotype in mice, DNA Repair, 2022, 120: 103410. (SCI期刊论文)
Ma, Rong; Kutchy, Naseer A.; Chen, Liang; Meigs, Douglas D.; Hu, Guoku*; Primary cilia and ciliary signaling pathways in aging and age-related brain disorders, Neurobiology of Disease, 2022, 163: 105607. (SCI期刊论文)
Zhang, Tianjiao; Chen, Liang; Li, Rongzhen; Liu, Ning; Huang, Xiaobing; Wong, Garry; PIWI-interacting RNAs in human diseases: databases and computational models, Briefings in Bioinformatics, 2022, 23(4). (SCI期刊论文)
Xuan Wu; Jizong Han; Di Wang; Pengyue Gao; Quanlong Cui; Liang Chen; Yanchun Liang; Han Huang; Heow Pueh Lee; Chunyan Miao; You Zhou; Chunguo Wu; Incorporating Surprisingly Popular Algorithm and Euclidean distance-based adaptive topology into PSO, Swarm and Evolutionary Computation, 2023, 76: 101222. (SCI期刊论文)
Ma, Rong; Chen, Liang; Hu, Ningyun; Caplan, Steve; Hu, Guoku; Cilia and extracellular vesicles in brain development and disease, Biological Psychiatry, 2023. (SCI期刊论文)
Liu, Yijun; Song, Fuhu; Li, Zhi; Chen, Liang; Xu, Ying; Sun, Huiyan*; Chang, Yi*; A comprehensive tool for tumor precision medicine with pharmaco-omics data analysis, Frontiers in Pharmacology, 2023, 14: 1085765. (SCI期刊论文)
王慧; 张培培; 蔡润林; 陈亮; 杜虹; 胡忠; 《生物信息学》课程的跨学科教学模式探索与实践, 汕头大学学报(自然科学版), 2022, 37(2): 75-80. (期刊论文)
Liang Chen; Garry Wong*; Transcriptome Informatics, Reference Module in Life Sciences, Null, Elsevier, Netherlands, 2019. (书籍章节)
Annadurai Thangaraj; Palsamy Periyasamy; Liang Chen; Naseer A. Kutchy; Guoku Hu; Shilpa Buch; Noncoding RNAs and Epigenetic Regulation in Aging, Reference Module in Food Science, Null, Elsevier, Netherlands, 2020. (书籍章节)
Ma, Rong; Chen, Liang; Hu, Guoku*; Extracellular Vesicles: Therapeutic Delivery, Neuroimmune Pharmacology and Therapeutics, Gendelman, Howard E., Springer Nature, 855--871, Switzerland, 2024. (书籍章节)
科研项目：
国家自然科学基金青年科学基金项目，62002212，关于阿尔茨海默病非编码RNA生物标志物挖掘的研究，2021/01-2023/12，主持
广东省自然科学基金-面上项目，2025A1515012810，基于深度学习的泛神经退行性疾病多组学数据整合研究，2025/01-2027/12，主持
国家自然科学基金面上项目，2373177，质粒水平转移对牛蛙养殖场中耐药基因组的形成、演化和防治研究，2024/01-2027/12，参加
国家科技重大专项，2024ZD0529106，睡眠呼吸障碍疾病新型诊疗技术与综合管理模式研究（子课题：基于SDB多治疗精准队列的疗效预测模型构建及综合治疗模式建立与评价），2025.02-2029.01，参加
澳门大学多年研究项目，MYRG2016-00101-FHS，“非经典非编码小RNA的数据库构建，表达分析与生物标志物挖掘”，2017/01-2019/12，参加
国家自然科学基金青年科学基金项目，61602207，开放获取生物医学文献的实体关系抽取，2017/01-2020/12，参加
国家自然科学基金面上项目，61572227，胰腺癌体液肿瘤标志物的系统挖掘与机理分析，2016/01-2019/12，参加
国家自然科学基金面上项目，61572228，永恒语言学习关键算法研究，2016/01-2019/12，参加
国家自然科学基金面上项目，61472158，全基因组重测序数据高维SNP相互作用研究，2015/01-2018/12，参加
国家自然科学基金面上项目，11372117，微机电系统多尺度力学问题研究与实验验证，2014/01-2017/12，参加
国家自然科学基金面上项目，61272207，基于农作物高通量表达谱数据的特征选择与分子网络构建的评估算法，2013/01-2016/12，参加
教育部博士点基金，20120061120106，基于表达数据的癌症miRNA标志物预测及网络构建研究，2013/01-2014/12，参加
吉林省科技厅国际合作项目，20120730，结肠癌与食道癌早期诊断的尿液中蛋白标志物预测，2012/01-2014/12，参加
国家自然科学基金面上项目，61073075，农艺性状及相关基因关联网络若干基础问题研究，2011/01-2013/12，参加
