姓 名： 张明
联系方式：13539623260(M)
E-mail: zhming90@163.com/ zhming90@stu.edu.cn
● 个人简介：
张明，男，1990年8月生，中共党员，湖南邵阳人，2022年毕业于汕头大学，并于2022至2024年在汕头大学从事博士后研究。汕头大学讲师，汕头大学理学院工会委员会委员，广东省动物学会，广东水产学会会员，2024年入选汕头大学卓越人才支持计划（优秀青年人才）。
目前主要从事拟穴青蟹肠道外泌体在抗菌免疫中的研究以及海洋无脊椎动物病害与免疫分子调控机制的研究。目前已主持国家自然科学基金青年科学基金项目，广东省自然科学基金面上项目，广西自然科学基金面上项目及福建省水产功能性饲料及养殖环境调控重点实验室2023年度开放课题等项目4项，参加国家自然科学基金等项目8项。
在Food Research International, mSystems, Aquaculture, Aquaculture Reports, Fish Shellfish Immunology, Developmental Comparative Immunology, Journal of Immunology, Journal of Biological Chemistry, Journal of Virology, Applied Environmental Microbiology等国内国际学术刊物发表论文35篇，其中以第一/共一及共同通讯作者发表SCI论文9篇。论文被引次数达到500余次，H-index为13；授权国家发明专利3项，申请专利在审4项，目前担任Aquaculture，Frontiers in Immunology，Fish & Shellfish Immunology, Frontiers in Microbiology，Frontiers in Marine Science，International Journal of Immunology等多个SCI期刊审稿人。
● 教育经历：
2018/9–2022/6，汕头大学，海洋生物学，博士，导师：李升康教授
2014/9–2017/7，汕头大学，海洋生物学，硕士，导师：李升康教授
2010/9–2014/7，长江大学，生物技术，学士
● 工作经历：
2017/8–2018/7，阳江职业技术学院，科研助理
2022/7–2022/9，汕头大学，生物学博士后
2022/9–至今，汕头大学，讲师
● 主持及参与项目情况：
1. 国家自然科学基金青年科学基金：32303052，拟穴青蟹外泌体miR-876调控肠道上皮细胞增殖的分子机制及免疫学意义，2024.1-2026.12，30万元，主持
2. 广东省自然科学基金面上项目：2024A1515011613，外泌体miR-448调控青蟹肠道抗副溶血弧菌感染分子机制及免疫学意义，2024.1-2026.12，15万元，主持
3. 福建省水产功能性饲料及养殖环境调控重点实验室2023年度开放课题：FACE20230005，鱼源产丁酸菌对大口黑鲈肠道健康的影响，2024.1-2025.12，3万元，主持
4. 广西自然科学基金面上项目：拟穴青蟹外泌体bta-miR-3533调控肠道细胞凋亡的分子机制研究，2025.1-2027.12, 10万元，主持
5. 福建省种业创新与产业化工程：仿刺参高效健康养殖关键技术研究与应用，2021.1-2025.12，30元，参加-
6. 国家自然科学基金面上项目：32173006，外泌体miRNA调控拟穴青蟹血淋巴群稳态的分子机制研究，2022.1-2025.12，59万元，参加
7. 国家自然科学基金面上项目：42076125，外泌体miRNAs调控拟穴青蟹抗副溶血弧菌感染的分子机制研究，2021.1-2024.12，58万元，参加
8. 广东省高等学校自然科学研究重点项目：2021ZDZX4018，具有益生效果的海水鱼肠道来源的丁酸菌资源库的构建及评估，2022.1-2024.11，12万元，参加
9. 广东省普通高校重点领域专项项目(自然科学)：2022ZDZX4007，丁酸梭菌改善浅色黄姑鱼肠道免疫的功能研究与水产养殖应用评估，2022.9-2024.8，12万元，参加
10. 国家自然科学基金面上项目：41876152，ECSIT介导的线粒体ROS途径在拟穴青蟹血淋巴菌群稳态调控中的作用及分子机制, 2019.01-2022.12, 62万元, 参加
11. 广东省科技计划重点项目：2017B020204003，拟穴青蟹工厂化养殖关键技术与示范， 2017.01-2020.12，100万元，参加
12. 国家自然科学青年基金：41706185，拟穴青蟹血淋巴共生微生物菌群的代谢功能多样性研究，2017.01-2018.12，25万元，参加
13. 国家自然科学基金项目：41641053, 拟穴青蟹肠道菌群抗病毒感染及其分子机理研究，2017.1-2017.12，23.6万元，参加
● 主要研究成果：
1. 文章发表情况
一作或通讯文章：
1) Zhang M#, Tran NT#, Ji PN, Zhang YS, Zhang DM, Zheng HP, Li SK. Transcriptome analysis provides insights into the high ability to synthesize fatty acids in “yellow oil” mud crab (Scylla paramamosain). Food Res Int. 2023, 172: 113213. (IF=8.1, JCR:Q1 农林科学一区Top)
2) Zhang M, Tran NT, Zhang YS, Yang QH, Tang Y, Zhang YL, Li SK. SpNox regulates the homeostasis in the hemolymph and gut of mud crab (Scylla paramamosain) by generating ROS. Aquaculture, 2023, 575(9): 739760. (IF=4.5, JCR:Q1, 农林科学一区Top)
3) Zhang M#, Liang HF#, Lei YF, Zhang YW, Tan ZG, Chen WZ, Li SK, Peng XF, and Tran NT. Aspergillus niger confers health benefits and mosdulates the gut microbiota of juvenile Pacific white shrimp (Penaeus vannamei) under farming conditions. Front Mar Sci. 2023, 10: 1211993. (IF=3.7, JCR:Q1, 生物学二区)
4) Zhang M#, Zhang XX#, Tran NT, Sun ZQ, Zhang XS, Ye HH, Zhang YL, Ma HY, Aweya JJ, Li SK. Molting alters the microbiome, immune response, and digestive enzyme activity in mud crab (Scylla paramamosain). mSystems, 2021, 6: e00917-21. (IF=6.4, JCR:Q1, 生物学二区)
5) ZhangM#, Ji PN#, Li ZZ, Sun ZQ, Tran NT, Li SK. Catalase regulates the homeostasis of hemolymph microbiota and autophagy of the hemocytes in mud crab (Scylla paramamosain). Aquacult Rep.2022, 25: 101237.(IF=3.7, JCR:Q1, 农林科学二区)
6) Zhang XX#, Zhang M#, Zheng HP, Ye HH, Zhang XS, Li SK. Source of hemolymph microbiota and their roles in the immune system of mud crab. Dev Comp Immunol. 2019, 102: 103470. (IF=2.9, JCR:Q1, 生物学三区)
7) Wei ZB#, Zhang M#, Chen Y, Hu H, Zhao XS, Zheng YQ, Tran NT, Feng HP, Zeng C, Li SK. Spätzle maintains homeostasis of hemolymph microbiota in Scylla paramamosain through Toll2. Fish Shellfish Immunol. 2024. 146: 109385. (IF=4.7, JCR:Q1, 农林科学二区Top)
8) Lei YF#, Zhang M#, Huang KY, Sun Q, Li JK, Liang HF, Zheng YQ, Tran NT, Chen XL, Zhang YQ, Zhang YL, Li SK. Ca2+-SpVAMP2 pathway promotes exosome secretion to resist the infection of Vibrio parahaemolyticus in mud crab (Scylla paramamosain). Aquaculture, 2024, 596(1): 741766. (IF=4.5, JCR:Q1, 农林科学一区Top)
9) Yang W#, Liang HF#, Chen RH, Du ZN, Deng TQ, Zheng YQ, Song Y, Duan YC, Lin JY, Bakky MAH, Tran NT*, Zhang M*(共同通讯), Li SK*. Effects of dietary probiotic (Clostridium butyricum I9, C. butyricum G15, or Paraclostridium bifermentans X13) on growth, digestive enzyme activities, immunity, and intestinal microbiota of Pacific white shrimp (Penaeus vannamei). Front Microbiol, 2024, 15: 1479446.
10) Sun Q, Lin SM, Zhang M, Gong Y, Ma HY, Tran NT, Zhang YL, Li SK. SpRab11a-regulated exosomes inhibit bacterial infection through the activation of anti-lipopolysaccharide factors in crustaceans. J Immunol. 2022, 209(4): 710-722. (IF: 4.4, JCR:Q1; 医学二区Top).
11) Sun Q, Yang JW, Zhang M, Zhang YS, Ma HY, Tran NT, Chen XL, Zhang YL, Chan KG, Li SK. Exosomes drive ferroptosis by stimulating iron accumulation to inhibit bacterial infection in crustaceans. J Biol Chem. 2023, 299(12): 105463. (IF=4.8, JCR:Q1, 生物学二区Top)
12) Zhang XX, Sun ZQ, Zhang XS, Zhang M, Li SK. Hemolymph microbiomes of three aquatic invertebrates as revealed by a new cell extraction method. Appl Environ Microb. 2018, 84: e02824-17. (IF=4.4, JCR:Q2, 生物学二区Top)
13) Wei XY, Wang LM, Sun WW, Zhang M, Ma HY, Zhang YL, Zhang XX, Li SK. C-type lectin B (SpCTL-B) shows strong agglutination and antimicrobial activities and is involved in phagocytosis in Mud crab Scylla paramamosain, Dev Comp Immunol. 2018, 84: 213-229. (IF=2.9, JCR:Q1, 生物学三区)
14) Zhang DM, WanWS, Kong TT, Zhang M, Aweya JJ, Gong Y, Li SK. A clip domain serine protease regulates the expression of proPO and hemolymph clotting in mud crab, Scylla paramamosain.Fish Shellfish Immunol. 2018, 79:52-64. (IF=4.7, JCR:Q1, 农林科学二区Top)
15) Sun ZQ, Hao SF, Gong Y, Zhang M, Jude J, Tran NT, Zhang YL, Ma HY, Li SK. Dual oxidases participate in the regulation of hemolymph microbiota homeostasis in mud crab Scylla paramamosain. Dev Comp Immunol, 2018, 89:111-121. (IF=2.9, JCR:Q1, 生物学三区)
16) Yang QH, Sun ZQ, Zhang M, Tran NT, Gong Y, Fan JH, Lu Z, Zhou C, Zhang YL, Li SK. Spp38 MAPK participates in maintaining the homeostasis of hemolymph microbiota in Scylla paramamosain. Dev Comp Immunol. 2019, 95:38-49. (IF=2.9, JCR:Q1, 生物学三区)
17) Yang QH, Lü YL, Zhang M, Gong Y, Li ZZ, Tran NT, He YY, Zhu CH, Lu YS, Zhang YL, Li SK. Lactic acid bacteria, Enterococcus faecalis Y17 and Pediococcus pentosaceus G11, improved growth performance, and immunity of mud crab (Scylla paramamosain). Fish Shellfish Immunol. 2019, 93:135-143. (IF=4.7, JCR:Q1, 农林科学二区Top)
18) Tran NT, Kong TT, Zhang M, Li SK. Pattern recognition receptors and their roles on the innate immune system of mud crab (Scylla paramamosain). Dev Comp Immunol. 2019, 102: 103469. (IF=2.9, JCR:Q1, 生物学三区)
19) Gong J, Shi WY, Zhang M, Wang TF, Yu K, Ye HH. Characterization and expression analysis of E75 during ovarian development and juvenile growth of the mud crab, Scylla paramamosain Estampador, 1950 (Brachyura, Portunidae). Crustaceana. 2019, 92, 9:1063-1079. (IF=0.6, JCR:Q4, 生物学四区)
20) Tran NT, Tang Y, Li ZZ, Zhang M, Wen XB, Ma HY, Li SK. Galactooligosaccharides and resistant starch altered microbiota and short-chain fatty acids in an in vitro fermentation study using gut contents of mud crab (Scylla paramamosain). Front Microbiol, 2020, 11: 1352. (IF=5.2, 生物学二区Top)
21) Yang W, Tran NT, Zhu CH, Zhang M, Yao DF, Aweya JJ, Gong Y, Ma HY, Zhang YL, Li GL, Li SK. Enhanced immune responses and protection against the secondary infection in mud crab (Scylla paramamosain) primed with formalin-killed Vibrio parahemolyticus. Aquaculture. 2020, 529: 735671. (IF=4.5, JCR:Q1, 农林科学一区Top)
22) Tran NT, Yang W, Nguyen XT, Zhang M, Ma HY, Zheng HP, Zhang YL, Chan KG, Li SK. Application of heat-killed probiotics in aquaculture. Aquaculture, 2022, 548(2), 737700. (IF=4.5, JCR:Q1, 农林科学一区Top)
23) Tran NT, Liang HF, Zhang M, Bakky MAH, Zhang YL, Chan KG, Li SK. Role of Cellular Receptors in the Innate Immune System of Crustaceans in Response to White Spot Syndrome Virus. Viruses. 2022, 14: 743. (IF=4.7, JCR:Q2, 医学三区)
24) Tran NT, Liang HF, Li JK, Deng TQ, Zhang M, Li SK. Health benefits of butyrate and its producing bacterium, Clostridium butyricum, on aquatic animals. Fish Shellfish Immunol Rep. 2023, 4: 100088.
25) Tran NT, Chen LJ, Zhou YL, Zhang M, Wang YL, Li SK. SpTNF regulates apoptosis and antimicrobial peptide synthesis in mud crab (Scylla paramamosain) during white spot syndrome virus infection. Fish Shellfish Immunol. 2023, 139: 108881. (IF=4.7, JCR:Q1, 农林科学二区Top)
26) Bakky MAH, Tran NT, Zhang M, Zhang YS, Liang HF, Wang YL, Zhang YL, Ma HY, Zheng HP, Li SK. In vitro fermentation of Gracilaria lemaneiformis and its sulfated polysaccharides by rabbitfish gut microbes. Int J Biol Macromol. 2023, 246: 125561. (IF=8.2, JCR:Q1, 化学一区Top)
27) Bakky MAH, Tran NT, Zhang Y, Hu H, Lin H, Zhang M, Liang H, Zhang Y, & Li S. Effects of dietary supplementation of Gracilaria lemaneiformis-derived sulfated polysaccharides on the growth, antioxidant capacity, and innate immunity of rabbitfish (Siganus canaliculatus). Fish Shellfish Immunol. 2023, 139: 108933. (IF=4.7, JCR:Q1, 农林科学二区Top)
28) Liang HF, Tran NT, Deng TQ, Li JK, Lei YF, Bakky MAH, Zhang M, Li R, Chen WX, Zhang YL, Chen XL, Li SK. Identification and Characterization of a Potential Probiotic, Clostridium butyricum G13, Isolated from the Intestine of the Mud Crab (Scylla paramamosain). Microbiol Spectr. 2023, 11(4), e0131723. (IF=3.7, JCR:Q1, 生物学一区Top)
29) Zhang YS, Ji PN, Zhang M, Tran NT, Li SK. Large-scale lysine crotonylation analysis reveals the role of TRAF6-Ecsit complex in endoplasmic reticulum stress in mud crab (Scylla paramamosain). Dev Comp Immunol. 2023, 148: 104898. (IF=2.9, JCR:Q1, 生物学三区)
30) Tran NT, Liang HF, Li JK, Deng TQ, Bakky MAH, Zhang M, Li SK. Cellular responses in crustaceans under white spot syndrome virus infection. Fish Shellfish Immunol. 2023, 140: 108984. (IF=4.7, JCR:Q1, 农林科学二区Top)
31) Zhang YS, Liu T, Sun Q, Zhang M, Tran NT, Chen XL, Li SK. Exosomal SpFlotillin-1 participates in resistance to Vibrio parahemolyticus infection in mud crab (Scylla paramamosain). Aquaculture. 2023, 580(1): 740318. (IF=4.5, JCR:Q1, 农林科学一区Top)
32) Yang QH#, Zhong YF#, Yang FY, Li HY, Tran NT, Zhang M, Wang LL, He LB, Zhang Z, Ge H, Wu JS, Ai CX, Li SK, Lin Q. Transcriptome analysis of sea cucumber (Apostichopus japonicus) in southern China under heat stress. Aquacult Rep. 2024, 36: 102036. (IF=3.7, JCR:Q1, 农林科学二区).
33) Gong Y, Hu H, Zhao XS, Wei WQ, Zhang M, Tran NT, Ma HY, Zhang YL, Chan KG, Li SK. Exosome-mediated viral nucleic acid presentation in a crustacean expounds innate immunity from a novel perspective. Journal of Virology. 2024, 98(12): e0151924.
34) Bakky MAH, Tran NT, Zhang M, Wang SQ, Zhang YL, Li SK. Synergistic effects of butyrate-producing bacteria (Clostridium senegalense I5 or Paraclostridium benzoelyticum G5) and Gracilaria lemaneiformis-originated polysaccharides on the growth and immunity of rabbitfish. Int J Biol Macromol. 2024, 138683.
35) Li ZZ#, Tran NT#, Zhang M, Li ZX, Yang WY, Wang SQ, Hu Z, Li SK. Isolation and Evaluation of Potential Use of Prebiotics -Utilizing Butyrate-Producing Bacteria in Nibea coibor. Aquaculture Nutrition. 2025, 4679037. doi.org/10.1155/anu/4679037
36) Sun Q#, Yun LY#, Hu KC, Li H, Li PF, Lu YY, Gao RW, Zhang M, Tran NT, Chen XL, Zhao YZ, Zhang YL, Li SK. The outer membrane vesicles of Vibrio parahaemolyticus elicit innate immune responses in mud crab (Scylla paramamosain). 2025, 601: 742289.
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2. 专利申请情况
1) 李升康，张新旭，张明，张旭昇，孙再桥。一种准确计数无脊椎动物血淋巴中微生物丰度的方法。ZL201711249372.8，授权时间：2021.8.16。
2) 李升康, 李忠贞, 纪培娜, 张明。一株具有益生活性的丁酸梭菌CG3的筛选和鉴定。ZL201910361908.8, 授权时间：2022.12.06。
3) 李升康, 赵永贞, 孙倩, 章跃陵, 彭敏, 张明, 张彬, 刘青云。一种水生动物中高效递送基因编辑质粒的方法。ZL202410192395.3, 授权时间：2024.12.13.
4) 李升康，孙倩，张勇胜，张明。一种甲壳动物血细胞人工外泌体的制备方法，CN202211465018.X。
5) 李升康，宋莹，云琳颖，张明，梁惠芬，林海天。一种拟穴青蟹精原干细胞的体外培养方法，CN202310166441.8。
6) 李升康，陈玉俊，章跃陵，邓桃球，梁惠芬，张明，赵永贞，彭敏，刘青云，陈秀荔，曾地刚，杨春玲。一种海水养殖复合丁酸菌剂及其制备方法和应用，CN202311765249.7。
李升康，孙倩，张明，章跃陵。一种甲壳动物体内基因过表达的方法。CN202310613942.6。
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