张薄博
个人信息
性别：男 出生年月：1982年10月
籍贯：广东汕头 政治面貌：中共党员
汕头大学 理学院 生物系 教授 博导
Email: bbzhang@stu.edu.cn
教育背景
2008/08 – 2011/12，香港中文大学(The Chinese University of Hong Kong)，生物学，博士
2005/09 – 2008/07，华南理工大学，发酵工程，硕士
2001/09 – 2005/07，华南理工大学，生物工程，学士
工作经历
2020/01 – 至今 汕头大学，理学院，生物系，教授
2012/01 – 2019/12 江南大学，生物工程学院，副教授
2014/06 – 2016/01 欧洲科学院苏宝连院士课题组，博士后
2017/06 – 2019/12 江苏康能，科技副总（兼职，2018江苏省“双创计划”）
研究领域 （发酵工程，食品与生物医药）
（1）食药真菌发酵合成活性产物的研究：包括红曲天然(红、橙、黄)色素和活性产物(降脂物质洛伐他汀等)，牛樟芝中具有显著抗癌、护肝等活性的代谢产物的生物合成与发酵调控，桦褐孔菌、桑黄等药用真菌发酵，蘑菇活性多糖等方面的研究
（2）生命复合材料&生物催化：包括利用生命复合材料合成高价值代谢产物，微生物细胞催化在食品和医药中的应用
（3）食品废弃物的生物综合利用：利用甘蔗渣、玉米芯、豆渣、麦糟、茶梗、低次烟叶等废弃物作为食药用真菌固态发酵的基质，生产高附加值产品
科研项目
2012年以来，主持或参与十三五国家重点研发计划项目，欧盟FOTOBIOMAT项目，863计划、十二五项目、国家自然科学基金、江苏省自然科学基金等纵向科研项目10项，企业横向科研项目3项。代表性的科研项目如下:
[1] 红曲黄色素的工业化生产及稳态化技术研究，十三五国家重点研发计划“食品添加剂与配料绿色制造关键技术”（Grant No. 2016YFD0400802子课题主持，136万）
[2] 枯草芽孢杆菌和红曲菌共培养诱导天然黄色素合成的分子机制，国家自然科学基金-面上项目（Grant No. 32072184，主持，58万）
[3] 樟芝菌丝体安卓奎诺尔生物合成的调控机理研究，国家自然科学基金-青年项目（Grant No. 21306065，主持，25万）
[4] 基于蛋白质组学的樟芝液态发酵活性代谢产物的生物合成机制研究，江苏省自然科学基金-青年项目（Grant No. BK20130134，主持，20万）
[5] 樟芝特有活性物质Antroquinonol的分子合成及调控应答机制研究，江苏省自然科学基金-面上项目（Grant No. BK20181348，主持，10万）
[6] 红曲天然黄色素的绿色制造，北京市食品添加剂工程技术中心开放课题（主持，5万）
[7] 红曲黄色素提取精制技术的研究开发，横向-企业合作项目（主持，30万）
[8] 樟芝活性产物的检测、分析和纯品制备技术，横向-企业合作项目（主持，30万）
[9] 乳杆菌中抑菌物质的研究，横向-企业合作项目（主持，20万）
[10] 液态发酵樟芝菌丝体高产活性多糖的研究，中央高校基本科研专项资金（Grant No. JUSRP11219，主持，8万）
[11] FOTOBIOMAT欧盟项目（主要完成者/Coordinator）
[12] 固体发酵过程控制及智能化装备技术，863项目（参与）
发表论文
发表论文近40篇，其中以第一作者/通讯作者发表SCI论文25篇，按中科院期刊JCR分区，1 区 10篇，II区8篇：
[1] Bo-Bo Zhang*, Li Wang, Valérie Charles, Joanna C. Rooke, Bao-Lian Su*, Robust and biocompatible hybrid matrix with controllable permeability for microalgae encapsulation, ACS Applied Materials & Interfaces, 2016, 8: 8939–8946. (1区杂志IF=8.758)
[2] Bo-Bo Zhang*, Yu-Yan Guan, Peng-Fei Hu, Lei Chen, Gan-Rong Xu, Liming Liu, Peter C.K. Cheung. Production of bioactive metabolites by submerged fermentation of the medicinal mushroom Antrodia cinnamomea: recent advances and future development. Critical Reviews in Biotechnology, 2019, 39: 541-554. (1区杂志IF=8.108)
[3] Bo-Bo Zhang, Peter C K Cheung*. A mechanistic study of the enhancing effect of Tween 80 on the mycelial growth and exopolysaccharide production by Pleurotus tuber-regium. Bioresource Technology, 2011, 102: 8323–8326. (1区杂志IF=7.539)
[4] Li Wang, Zhi-Yi Hu, Xiao-Yu Yang*, Bo-Bo Zhang*, Wei Geng, Gustaaf Van Tendelooce, Bao-Lian Su*, Polydopamine nanocoated whole-cell asymmetric biocatalyst. Chemical Communications, 2017, 53: 6617–6620. (1区杂志IF=5.996)
[5] Peng-Fei Hu, Jing Huang, Lei Chen, Zhongyang Ding, Liming Liu, István Molnár*, and Bo-Bo Zhang*. Oxidative stress induction is a rational strategy to enhance the productivity of Antrodia cinnamomea fermentations for the antioxidant secondary metabolite antrodin C. Journal of Agricultural and Food Chemistry, 2020, 68: 3995–4004. (1区杂志IF=4.192)
[6] Bo-Bo Zhang*, Peng-Fei Hu, Jing Huang, Yong-Dan Hu, Lei Chen, Gan-Rong Xu. Current advances on the structure, bioactivity, synthesis and metabolic regulation of novel ubiquinone derivatives in the edible and medicinal mushroom Antrodia cinnamomea. Journal of Agricultural and Food Chemistry, 2017, 65: 10395–10405. (1区杂志IF=4.192)
[7] Jun Lv, Gao-Fei Qian, Lei Chen, Huan Liu, Hai-Xiao Xu, Gan-Rong Xu, Bo-Bo Zhang*, Chan Zhang*. Efficient biosynthesis of natural yellow pigments by Monascus purpureus in a novel integrated fermentation system. Journal of Agricultural and Food Chemistry, 2018, 66: 918−925. (1区杂志IF=4.192)
[8] Bo-Bo Zhang, Peter C K Cheung*. Use of stimulatory agents to enhance the production of bioactive exopolysaccharide from Pleurotus tuber-regium by submerged fermentation. Journal of Agricultural and Food Chemistry, 2011, 59: 1210-1216. (1区杂志IF=4.192)
[9] Bo-Bo Zhang, Lei Chen, Peter C K Cheung*. Two-dimensional gel electrophoresis analysis of mycelial cells treated with Tween 80: Differentially expressed protein related to enhanced metabolite production. Journal of Agricultural and Food Chemistry, 2012, 60: 10585–10591. (1区杂志IF=4.192)
[10] Gao-Fei Qian, Jing Huang, Ardavan Farhadi, Bo-Bo Zhang*. Ethanol addition elevates cell respiratory activity and causes overproduction of natural yellow pigments in submerged fermentation of Monascus purpureus. LWT-Food Science and Technology, 2021, 139: 110534. (1区杂志IF=4.006)
[11] Bo-Bo Zhang, Jing Cheng, Wen-Yong Lou, Pan Wang, Min-Hua Zong*. Efficient anti-Prelog enantioselective reduction of acetyltrimethylsilane to (R)-1-trimethylsilylethanol by immobilized Candida parapsilosis CCTCC M203011 cells in ionic liquid-based biphasic systems. Microbial Cell Factories, 2012, 11: 108–120. (2区杂志IF=4.187)
[12] Yong-Dan Hu, Bo-Bo Zhang*, Gan-Rong Xu, Xiang-Ru Liao*, Peter C.K. Cheung, A mechanistic study on the biosynthetic regulation of bioactive metabolite Antroquinonol from edible and medicinal mushroom Antrodia camphorata. Journal of Functional Foods, 2016, 25: 70–79. (2区杂志IF=3.701)
[13] Bo-Bo Zhang, Li-Ping Lu, Yong-jun Xia, Yuan-Long Wang, Gan-Rong Xu*. Use of agar as carrier in solid-state fermentation for Monacolin K production by Monascus: a novel method for direct determination of biomass and accurate comparison with submerged fermentation. Biochemical Engineering Journal, 2013, 80: 10-13. (2区杂志IF=3.475)
[14] Huan Zhang, Yong-jun Xia, Yuan-Long Wang, Bo-Bo Zhang*, Gan-Rong Xu*. Coupling use of surfactant and in situ extractant for enhanced production of Antrodin C by submerged fermentation of Antrodia camphorata. Biochemical Engineering Journal, 2013, 79: 194-199. (2区杂志IF=3.475)
[15] Yong-Dan Hu, Huan Zhang, Rui-Qiu Lu, Xiang-Ru Liao, Bo-Bo Zhang*, Gan-Rong Xu*. Enabling the biosynthesis of Antroquinonol in submerged fermentation of Antrodia camphorata. Biochemical Engineering Journal, 2014, 91: 157-162. (2区杂志IF=3.475)
[16] Jing Huang, Kun Wang, Song Zuo, Lei Chen, Zhongyang Ding, Mohamed El-shazly, Bo-Bo Zhang*. Unsaturated fatty acid promotes the production of triterpenoids in submerged fermentation of Sanghuangporus baumii, Food Bioscience, 2020, 37: 100712. (2区杂志IF=3.067)
[17] Huan Zhang, Yong-Dan Hu, Rui-Qiu Lu, Yong-jun Xia, Bo-Bo Zhang*, Gan-Rong Xu*. Integrated strategy of pH‑shift and glucose feeding for enhanced production of bioactive Antrodin C in submerged fermentation of Antrodia camphorata. Journal of Industrial Microbiology & Biotechnology, 2014, 41: 1305–1310. (2区杂志IF=2.824)
[18] Yong-Hui Wang, Bo-Bo Zhang*, Li-Ping Lu, Yan Huang, Gan-Rong Xu*. Enhanced production of pigments by addition of surfactants in submerged fermentation of Monascus purpureus H1102. Journal of the Science of Food and Agriculture, 2013, 93: 3339–3344. (2区杂志IF=2.614)
[19] Bo-Bo Zhang, Li-Ping Lu, Gan-Rong Xu*. Why solid-state fermentation is more advantageous over submerged fermentation for converting high concentration of glycerol into Monacolin K by Monascus purpureus 9901: A mechanistic study. Journal of Biotechnology, 2015, 206, 60–65. (3区杂志IF=3.503)
[20] Bo-Bo Zhang, Lei Chen, Peter CK Cheung*. Proteomic insights into the stimulatory effect of Tween 80 on mycelial growth and exopolysaccharide production of an edible mushroom Pleurotus tuber-regium. Biotechnology Letters, 2012, 34: 1863-1867. (3区杂志IF=1.977)
[21] Bo-Bo Zhang, Wen-Yong Lou, Min-Hua Zong*, Hong Wu. Efficient synthesis of enantiopure (S)-4-(trimethylsilyl)-3-butyn-2-ol via asymmetric reduction of 4-(trimethylsilyl)-3-butyn-2-one with immobilized Candida parapsilosis CCTCC M203011 cells. Journal of Molecular Catalysis B- Enzymatic, 2008, 54: 122-129. (3区杂志IF=2.269)
[22] Jun Zhang, Yuan-Long Wang, Li-Ping Lu, Bo-Bo Zhang*, Gan-Rong Xu*. Enhanced production of Monacolin K by addition of precursors and surfactants in submerged fermentation of Monascus purpureus 9901. Biotechnology and Applied Biochemistry, 2014, 61: 202–207. (3区杂志IF=1.638)
[23] Yong-Dan Hu, Rui-Qiu Lu, Xiang-Ru Liao, Bo-Bo Zhang*, Gan-Rong Xu*. Stimulating the biosynthesis of antroquinonol by addition of effectors and soybean oil in submerged fermentation of Antrodia camphorata. Biotechnology and Applied Biochemistry, 2016, 63: 398–406. (3区杂志IF=1.638)
[24] Jun Lv, Bo-Bo Zhang*, Xiao-Dong Liu, Chan Zhang, Lei Chen, Gan-Rong Xu, Peter C.K. Cheung, Enhanced production of natural yellow pigments from Monascus purpureus by liquid culture: The relationship between fermentation conditions and mycelial morphology. Journal of Bioscience and Bioengineering, 2017, 124, 452–458. (3区杂志IF=2.366)
[25] Bo-Bo Zhang*, Hong-Bo Xing, Bing-Jie Jiang, Lei Chen, Gan-Rong Xu, Yun Jiang, Da-Yong Zhang. Using millet as substrate for efficient production of monacolin K by solid-state fermentation of Monascus ruber. Journal of Bioscience and Bioengineering, 2018, 125, 333–338. (3区杂志IF=2.366)
出版著作
[1] Ganrong Xu, Bobo Zhang. (2013) Solid-State Fermented Condiments and Pigments, pp 217-286. In: Jian Chen, Yang Zhu (eds) Solid State Fermentation for Foods and Beverages. CRC Press, Taylor &Francis Group, ISBN 978-1-4398-4496-0
[2] Lei Chen, Bobo Zhang*. (2019) Microbial Production of Natural Food Colorants, pp 129-158. In: Long Liu, Jian Chen (eds) Systems and Synthetic Biotechnology for Production of Nutraceuticals. Springer, Singapore, ISBN 978-981-15-0445-7
专利 申请发明专利15项，其中7项已获授权。
一种促进红曲菌液态发酵生产红曲黄色素的方法, CN201611250604.7
一种促进牛樟芝液态发酵生产Antrodin C 的方法，CN201810199956.7
一种提高桦褐孔菌液态发酵桦褐孔菌醇产量的方法，CN201910635372.4
一种提高桑黄液态发酵三萜产量的方法，CN201911340118.8
一种萃取红曲黄色素的方法, CN201710216652.2
一种促进红曲菌液态发酵生产红曲橙色素的方法，CN201710071293.6
一种促进樟芝液态发酵生物合成安卓奎诺尔的方法，CN201310739681.9
学术兼职和国际报告
[1] 学术兼职: 中国中药协会牛樟芝专业委员会常务委员，中国生物工程学会终身会员，中国菌物学会终身会员，美国食品科学技术学会（IFT）会员，Biotechnology Advances, Journal of Agricultural and Food Chemistry等顶级SCI期刊的兼职审稿人。
[2] 国际学术会议重要职务: 欧盟FOTOBIOMAT项目进展报告/年会/连续资助申报的组织者；2015 年Advanced Complex Inorganic Nanomaterials (ACIN)组委会成员
[3] 国际会议报告: 9th International Conference on Mushroom Biology and Mushroom Products, IFT Annual Meeting & Food Expo, 5th Cross-Strait Symposium on Food and Biotechnology, 1st International Symposium of Food Science and Human Wellness等多个国际会议上做过报告。
表彰奖励
[1] 广东省优秀硕士论文获得者 (省级；2010年)
[2] IFT（美国食品科学学会）研究论文竞赛第二名 (国际会议；2010年)
[3] “至善青年学者” (江南大学；2013年)
[4] 欧盟FOTOBIOMAT项目优秀完成者 (国际项目，比利时，2016年)
[5] 扬州市“绿扬金凤计划” 优秀博士资助对象（市级，2017年）
[6] 江苏省“双创计划”科技副总项目入选对象（省级，2018年）
[7] The 9th ICMBMP Excellent Presentation Award第九届世界食用菌生物学与产品大会杰出报告奖（国际会议，TOP 5%；2018年）
[8] ELSEVIER Outstanding Contribution in reviewing (爱思唯尔英文期刊杰出审稿人) DYES AND PIGMENTS 2016年度: Journal of Bioscience and Bioengineering 2018年度
教学及指导学生
2008-2011 《Food chemistry》、《Food technology》 助教，香港中文大学
2012-2019 《发酵工程原理与技术》、《食品发酵技术》 主讲，江南大学
2020-至今 《酶工程》、《食品感官评价》、《食品发酵技术》 主讲，汕头大学
在读博士生1人，硕士生6人；
已毕业：博士生2人（协助指导），硕士生8人。
其中3位学生获得国家奖学金奖励，1位学生获得江苏省优秀硕士论文称号。
|